When it comes to treating cancer, testing done by the NIH found 7 new compounds for treating cancer in the Honey Locust. A total of 10 compounds were found, and all were available for treating cancers. They tested these compounds against breast, cervical, larynx, and colon cancer cells and it was effective but most effective in Colon but still showed cell death in all of them. The studies done by China has shown that using the extract in an ointment has an effect against Chemotherapy skin damage. Also applied to skin it is effective for actinic keratosis or solar keratosis even called senile keratosis. This is a patch of skin that could develop into cancer but is slow growing, scaly and usually in areas exposed to the sun. It can also be used in basal cell skin cancers and skin warts.

They synthesized  the compounds and now use it as an IV drug in Chemotherapy for colorectal, oesophageal, stomach, pancreatic,breast and cervical cancer. 

The NIH found that the old wives tales of treating cancer with Honey Locust were deemed to be true. Yes they actually admitted it in the paper.